Black Family Stem Cell Institute BFSCI BFSCI

BFSCI Mission Statement

The Black Family Stem Cell Institute has been established at the Mount Sinai School of Medicine to create a comprehensive research program that fosters the study of stem cell biology. Research in stem cell biology hold great promise for developing new treatments for many diseases through replacement Rendl Lab of non-functional or malignant cell populations. Stem cells could potentially provide the basis for replacement therapies in diseases such as type I Diabetes, Parkinson, cardiovascular, and liver disease, and in cancers. Realization of these goals will require an understanding of the mechanisms responsible for the establishment of different organ systems in the embryo and for the maintenance of their function in the adult.

The community of stem cell biologists at Mount Sinai is committed to translating the great promise of stem cell biology to clinical advances at the bedside in a timely and safe manner. Both embryonic and tissue restricted adult stem cells will be investigated in an environment where interdisciplinary collaborations are encouraged, and facilitated. The ultimate goal of scientists at the Black Family Stem Cell Institute is to improve our understanding of the behavior of stem cell in order to manipulate their fate for the treatment of human diseases.

The Black Family Stem Cell Institute will include research on embryonic and adult stem cells. Given that embryonic stem (ES) cells are of early embryonic origin and have the potential to generate any cell type in the body, scientists at the Black Family Stem Cell Institute are committed to understanding the mechanisms that govern lineage induction, tissue specification and development in the normal embryo, with the goal of duplicating these processes in the ES Cell system. Adult stem cells are essential for the replacement of cells with finite life span and for the maintenance of tissues.

While the best characterized adult stem cells are those of the hematopoietic system, studies in recent years have provided strong evidence for the existence of stem cells in many other tissues, including the liver, skeletal muscle, brain and skin.

By integrating the biology of ES cells, embryonic development and adult stem cells, scientists will focus on building and /or expanding expertise in a number of different areas, including the hematopietic, cardiac, skeletal muscle, hepatocyte and pancreas systems.

Existing strengths in the biological research of several stem cell systems as well as expertise in bone marrow, liver and kidney transplantation in the clinic place Mount Sinai in a strong position to develop a broad stem cell program. The goal of the Black Family Stem Cell Institute is to realize such promise.