Chang Lab@Mount Sinai

Rui Chang, PhD

Assistant Professor

Department of Genetics and Genomic Sciences

Institute for Genomics and Multi-scale Biology

Mount Sinai School of Medicine

1425 Madison Ave, Office L3-70D

New York, NY 10029

Technical University of Munich, Germany

PhD in Computer Science

University of California, San Diego, USA

Postdoc in Computational Biology

The researches in Chang lab broadly cover the topics within the field of Systems Biology. In particular, we are focused on dissecting the multi-scale molecular interaction networks and signaling pathways in human diseases, such as cancer, aging-related disorder, Alzheimer and Psychiatric disease. We are also interested in modeling physiological dynamics during human developments, such as human embryonic stem cell guided differentitation, iPSC reprograming and trans-differentiation by developing and integrating cutting-edge reverse engineering approaches and statistical models.

Secondly, we are interested in reconstructing genome-wide and context-specific predictive network models of human cells to interrogate impact of underpinning biological process to the development of both physiological and pathological phenotypes and generate in-silico hypothesis in combination with laboratory validations towards next generation genetic therapy.

Thirdly, we are interested in developing computational model and algorithms towards personalized medicine and generate hypothesis for personalized drug repositioning.


Jan. 2015, Dr. Chang presented research paper on Pacific Symposium of Biocomputing, Big Island, Hawaii.