Thyroid Research Unit

Icahn school of medicine AT MOUNT SINai    
 James J PeTERS VA Medical Center campus
 

Director, Terry F. Davies MD, FRCP

Baumritter Professor of Medicine.

Contact Details:


Email: terry.davies@mssm.edu



Laboratory Address:


James J Peters VA Medical Center,

Research Division, Room 2F-28,

130 West Kingsbridge Road,
Bronx, NY 10468.


Phone:   718-220-6096

eFax:      212-428-6748

Mount Sinai Office:


Atran Berg Laboratory Building,

Floor 4,  Room 4-37,
100th St and Madison Ave,
New York, NY 10029.


Phone: 212-241-7429

Fax:     212-423-0508



MAILING ADDRESS:


Mount SInai Medical Center,

Box 1055,

1 Gustave L Levy Place,

New York, NY 10029.


CLINICAL APPOINTMENTS:


Click HERE for details.



              To learn more about some of our current research watch the interview:   http://www.medpagetoday.com/MeetingCoverage/ATA/48361
https://urldefense.proofpoint.com/v2/url?u=http-3A__www.medpagetoday.com_MeetingCoverage_ATA_48361&d=AAMF-g&c=4R1YgkJNMyVWjMjneTwN5tJRn8m8VqTSNCjYLg1wNX4&r=mcnSCUJFXqWtprs7zY41N8cX_QFy3Y-IkO1o3dkeWck&m=81reAdUNLRyszdfIr7LCKxJERFxuKws1HjAwfkwzwzI&s=toSAE5vppxoLCNOP5SLgIi5CjfgHuuWzvF6ALqC2_F8&e=shapeimage_2_link_0

    The main focus of our research  laboratory at the James J Peters VA Medical Center is thyroid autoimmune disease with the TSH receptor as the key molecule of interest. The TSH receptor (TSHR), a G protein coupled receptor on the basolateral surface of the thyrocytes, regulates  thyroid growth and metabolism. The TSHR is also the major auto antigen in human autoimmune thyroid disease such as Graves' disease (autoimmune hyperthyroidism). 

    Our laboratory studies  various aspects  of the TSHR including its genetic association with disease, the multiple post translational changes it undergoes and the important role, of TSHR  antibodies in thyroid autoimmune disease. In addition we have developed major activity in the areas of thyroid stem cells and the role of extra thyroidal TSHRs found in osteoclasts and osteoblasts.

Thyroid follicle derived from embryonic stem cells.

A TSHR-KO mouse examining the role of the thyroid.

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