Thyroid Research Unit

Mount sinai school of medicine    
 James J PeTERS VA Medical Center campus

The main focus of our research  laboratory at the James J Peters VA Medical Center is thyroid autoimmune disease with the TSH receptor as the key molecule of interest. The TSH receptor (TSHR), a G protein coupled receptor  on the basolateral surface  of the thyrocytes, regulates  thyroid growth and metabolism. Incidentally, it is also the major auto antigen in human autoimmune thyroid disease such as Graves' disease (autoimmune hyperthyroidism). 

    The laboratory studies  various aspects  of the TSH receptor including its genetic association with disease, the multiple post translational changes it undergoes and the important role, of TSHR  antibodies in thyroid autoimmune disease. In addition we have developed major activity in the areas of thyroid stem cells and the role of extra thyroidal TSHRs found in osteoclasts and osteoblasts. 

These studies are funded by the National Institutes of Health,  the VA Merit Award Program, the Mount Sinai School of Medicine and the James J. Peters VA Medical Center.home_files/PNAS-2002-Marians-15776-81.pdf
Director, Terry F. Davies MD, FRCP
Baumritter Professor of Medicine,
Mount Sinai School of Medicine.

Contact Details:


Laboratory Address:

James J Peters VA Medical Center,
Research Division, Room 2F-28
130 West Kingsbridge Road
Bronx, NY 10468

Phone:  718-220-6096
eFax:      212-428-6748

Mount Sinai Office:
Atran Berg Laboratory Building,
Floor 4,  Room 4-37
100th St and Madison Ave,
New York, NY 10029

Phone: 212-241-7429
Fax:     212-423-0508

Mount SInai Medical Center,
Box 1055,
1 Gustave L Levy Place,
New York,
NY 10029.

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