Joel Dudley, PhD (Principal Investigator)I am currently Assistant Professor of Genetics and Genomic Sciences and Director of Biomedical Informatics at Mount Sinai School of Medicine. Prior to Mount Sinai, I held positions as Co-founder and Director of Informatics at NuMedii, Inc. and Consulting Professor of Systems Medicine in the Department of Pediatrics at Stanford University School of Medicine, where I participated in leading research to incorporate genome sequencing into clinical practice (published in The Lancet, Cell, and PLoS Genetics). My current research is focused towards solving key problems in genomic and systems medicine through the development and application of translational and biomedical informatics methodologies. My published research covers topics in bioinformatics, genomic medicine, personal and clinical genomics, as well as drug and biomarker discovery. My recent work with co-authors describing a novel systems based approach for computational drug repositioning (published in Science Translational Medicine) was featured in the print edition of the Wall Street Journal, and earned designation as the NHGRI Director's Genome Advance of the Month. I am co-author (with Konrad Karczewski) of the forthcoming book Exploring Personal Genomics from Oxford University Press. I received a BS in Microbiology from Arizona State University and an MS and PhD in Biomedical Informatics from Stanford University School of Medicine.
Brian Kidd, PhDSenior Biomedical Informatics Research Scientist
Dr. Brian Kidd is a systems immunologist working on drug-immune cell interactions to better understand and treat immunological diseases. He specializes in analysis, integration, visualization, and interpretation of large-scale immunological data sets, focusing on developing applications for translational research to improve human health. Dr. Kidd earned his Ph.D. in Bioengineering and trained in Molecular Medicine at the University of Washington. Following his graduate work, Dr. Kidd joined Mark Davis’ lab and was a Bioinformatics Scientist at the Institute for Immunity, Transplantation, and Infection at Stanford University, where he developed computational methods for analyzing and integrating data sets from diverse components of human peripheral blood.
Ben Readhead, MBBSBiomedical Informatics Research Scientist
Lauren PetersPhD Student in Immunology
As a Ph.D. Student in Immunology at Mount Sinai School of Medicine, my research is focused on elucidating the causal drivers of Inflammatory Bowel Disease (IBD), which is comprised of Crohn’s disease (CD) and ulcerative colitis (UC), through the study of the functional outcome of genetic predisposition. There are at least 163 susceptibility loci, as defined by Genome Wide Association Studies (GWAS) associated with IBD, which span the majority of the pathways involved in maintenance of gut homeostasis. Our goal is to map these SNPs to specific loci and determine their relative organization and hierarchy. Through in silico perturbations of these networks, we can compare predicted outcomes with disease model validation to develop empirical networks in order to gain a better understanding of the master regulators and define core control hubs operating in innate and adaptive mucosal immunity as well as crosstalk with the gut epithelium and stroma. This will enable definition of the clinically heterogeneous and multifactoral IBD into molecular subsets to help guide therapeutic target and biomarker discovery as well as provide a framework for matching patient genetic predispositions with optimal clinical treatment.