Frenette Laboratory

Research

Videos: Bone Marrow

Supplemental Information for CD34+ Cell Homing to Bone Marrow

Explanatory Notes
Intravital microscopy of the parietal bone marrow microcirculation in a wild-type NOD/SCID mouse injected with fluorescently labeled human CD34+ cells. A large collecting venule and a network of sinusoids can be observed. Free-flowing cells circulate rapidly in the field of view while rolling cells move slowly on the endothelium of the bone marrow. In the second sequence, two cells have become firmly adherent on the vessel wall and one rolling cell will arrest momentarily and then will be released in the circulation.