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Research

Publications: Complete List

Original Peer-Reviewed Articles


Méndez-Ferrer S, Lucas D, Battista M, Frenette PS. Haematopoietic stem cell release is regulated by circadian oscillations. Nature 452, 442-447 (27 March 2008).

Chang J, Shi PA, Chiang EY, Frenette PS. Intravenous immunoglobulins reverse acute vaso-occlusive crises in sickle cell mice through rapid inhibition of neutrophil adhesion. Blood. 2008 Jan 15; 111(2):915-23. Epub 2007 Oct 11.

Hidalgo A, Peired AJ, Wild MK, Vestweber D, Frenette PS. Complete Identification of E-Selectin Ligands on Neutrophils Reveals Distinct Functions of PSGL-1, ESL-1, and CD44. Immunity, 2007, 26(4):477-89.

Chiang EY, Hidalgo A, Chang J, Frenette PS. Imaging receptor microdomains on leukocyte subsets in live mice. Nat. Methods. 2007 Mar;4(3):219-22.

Katayama Y, Battista M, Kao W, Hidalgo A, Peired A, Thomas SA, Frenette, PS. Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow. Cell 2006 124: 407-421.

Bogunovic M, Ginhoux F, Wagers A, Loubeau M, Isola LM, Lubrano L, Najfeld V, Phelps RG, Grosskreutz C, Scigliano E, Frenette PS, and Merad M. Identification of a cycling and radio-resistant dendritic cell population in mouse and human dermis: potential impact on graft versus host disease. J. Exp. Med. 2006 Nov 27;203(12):2627-38.

Angeli V, Ginhoux F, Llodra J, Quemeneur L, Frenette PS, Skobe M, Jessberger R, Merad M, Randolph GJ. B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity. 2006 Feb;24(2):203-15.

Hidalgo A, Frenette PS. Enforced fucosylation of neonatal CD34+ cells generates selectin ligands that enhance the initial interactions with microvessels but not homing to bone marrow. Blood, 2005, 105:567-75.

Katayama Y, Hidalgo A, Chang J, Peired A, Frenette PS. CD44 is a physiological E-selectin ligand on neutrophils. J Exp Med, 2005, 201:1183-9.

Katayama Y, Hidalgo A, Peired A, Frenette PS. Integrin alpha4beta7 and its counterreceptor MAdCAM-1 contribute to hematopoietic progenitor recruitment into bone marrow following transplantation. Blood, 2004, 104:2020-6.

Hidalgo A, Peired AJ, Weiss LA, Katayama Y, Frenette PS. The integrin alphaMbeta2 anchors hematopoietic progenitors in the bone marrow during enforced mobilization. Blood, 2004, 104:993-1001.

Turhan A, Jenab P, Bruhns P, Ravetch JV, Coller BS, Frenette PS. Intravenous immune globulin prevents venular vaso-occlusion in sickle cell mice by inhibiting leukocyte adhesion and the interactions between sickle erythrocytes and adherent leukocytes.Blood, 2004, 103:2397-400.

Martin AP, Coronel EC, Sano G, Chen S, Vassileva G, Canasto-Chibuque C, Sedgwick JD, Frenette PS, Lipp M, Furtado GC, and Lira SA. A Novel Model for Lymphocytic Infiltration of the Thyroid Gland Generated by Transgenic Expression of the Chemokine CC Chemokine Ligand 21. J. Immunol. 2004 Oct 15;173(8):4791-8.

Frenette J, Chbinou N, Godbout C, Marsolais D, Frenette PS. Macrophage, not neutrophil, infiltrates skeletal muscle in mice deficient in P/E selectin following mechanical reloading. Am J Physiol, 2003, 285:R727-32.

Katayama Y., Furie BC, Vestweber D, Furie B, Frenette PS. PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: Evidence for cooperation between E-selectin ligands and alpha4 integrin. Blood, 2003, 102:2060-2067.

Katayama Y, Frenette PS. Galactocerebrosides are required postnatally for stromal-dependent bone marrow lymphopoiesis. Immunity, 2003, 18:789-800.

Hidalgo A, Ma, S, Peired A, Weiss LA, Cunningham-Rundles C, Frenette PS. Insights into leukocyte adhesion deficiency type II from a novel mutation in the GDP-fucose transporter gene. Blood, 2003, 101: 1705-1712.

Hidalgo A, Weiss LA , Frenette PS. Functional selectin ligands mediating human CD34+ cell interactions with bone marrow endothelium are enhanced postnatally. J Clin Invest, 2002, 110: 559-569.

Turhan A., Weiss LA, Mohandas N, Coller BS, Frenette PS. Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm. Proc Natl Acad Sci USA, 2002, 99:3047-3051.

Frenette PS, Weiss L. Sulfated glycans induce rapid hematopoietic progenitor cell mobilization: evidence for selectin-dependent and independent mechanisms. Blood, 2000, 96: 2460-2468.

Frenette PS, Denis CV, Weiss L, Subbarao S, Harwig JH, Vestweber D, Wagner DD. P-selectin glycoprotein ligand-1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo. J Exp Med, 2000, 191:1413-1422.

Robinson SD, Frenette PS, Rayburn H, Cummiskey, M, Ullman-Cullere M, Wagner, DD, Hynes RO. Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment. Proc Natl Acad Sci USA, 1999, 96:11452-11457.

Enjyoji K, Sevigny J, Lin Y, Frenette PS, Christie PD, Schulte am Esch II J, Imai M, Edelberg JM, Rayburn H, Lech M, Beeler DL, Csizmadia E, Wagner DD, Robson SC, Rosenberg RD. Targeted disruption of CD39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Nat Med, 1999, 5:1010-1017.

Soriano SG, Wagner DD, Wang YF, Frenette PS. P-and E-selectin-deficient mice are susceptible to cerebral ischemia-reperfusion injury. Brain Res, 1999, 835:360-364.

Hartwell DW, Mayadas TN, Frenette PS, Rayburn H, Hynes RO, Wagner DD. Early inflammatory responses are compromised in mice expressing P-selectin with a deleted cytoplasmic domain. J Cell Biol, 1998, 143:1129-1141.

Frenette PS, Subbarao S, Mazo IB, von Andrian UH, Wagner DD. Endothelial selectins and VCAM-1 promote hematopoietic progenitor homing to bone marrow. Proc Natl Acad Sci USA, 1998, 95:14423-14428.

Hartwell DW, Butterfield K, Frenette PS, Kenton B, Hynes RO, Folkman J, Wagner DD. Normal angiogenesis in P- and E-selectin-deficient mice. Microcirculation, 1998, 5:173-178.

Homeister JW, Zhang M, Frenette PS, Hynes RO, Wagner DD, Lowe JB, Marks RM. E-and P-selectin function is redundant for neutrophil accumulation in acute dermal inflammation. Blood, 1998, 92:2345-2352.

Petri Seiler K, Ma Y, Weis JH, Frenette PS, Hynes RO, Wagner DD, Weis JJ. E-and P-selectin do not modulate susceptibility to murine Lyme arthritis. Infect Immun, 1998, 66: 4557-4559.

Mazo IB, Gutierrez-Ramos JC, Frenette PS, Wagner DD, Hynes RO, von Andrian UH. Stem cell interactions with bone marrow microvessels: Parallel contributions by endothelial selectins and VCAM-1. J Exp Med, 1998, 188:465-474.

Denis C, Methia N, Frenette PS, Rayburn H, Ullman-Cullere M, Hynes RO, Wagner DD. A mouse model of severe von Willebrand disease: Defect in hemostasis and thrombosis. Proc Natl Acad Sci USA, 1998, 95:9524-9529.

De Mora F, Williams CMM, Frenette PS, Hynes RO, Wagner DD, Galli SJ. P-and E-selectins are required for the leukocyte recruitment, but not the tissue swelling, associated with IgE- and mast cell-dependent inflammation in mouse skin. Lab Invest, 1998, 78:497-505.

Dong ZM, Chapman S, Brown AA, Frenette PS, Hynes RO, Wagner DD. The combined role of P-and E-selectins in atherosclerosis. J Clin Invest, 1998, 102:145-152.

Frenette PS, Moyna C, Hartwell DW, Lowe JB, Hynes RO, Wagner DD. Selectin-mediated platelet-endothelial interactions in inflamed mesenteric venules. Blood, 1998, 91:1318-1324.

Weiser MR, Pechet TTV, Williams JP, Ma M, Frenette PS, Moore FD, Kobzik L, Hynes RO, Wagner DD, Carroll MC, Hechtman HB. Experimental murine acid aspiration injury is mediated by neutrophils and the alternative complement pathway. J Appl Physiol, 1997, 83:1090-1095.

Walter UM, Ayer LM, Manning AM, Frenette PS, Wagner DD, Hynes RO, Wolitzky BA, Issekutz AC. Generation and characterization of a novel adhesion function blocking monoclonal antibody recognizing both rat and mouse E-selectin. Hybridoma, 1997, 16:355-361.

Subramaniam M, Saffaripour S, van de Water L, Frenette PS, Mayadas TN, Hynes RO, Wagner DD. Role of endothelial selectins in wound repair. Am J Pathol, 1997, 150:1701-1709.

Tang T, Frenette PS, Hynes RO, Wagner DD, Mayadas TN. Response to cytokine-induced meningitis is dramatically attenuated in endothelial selectin-deficient mice. J Clin Invest, 1996, 97:2485-90.

Frenette PS, Mayadas TN, Rayburn H, Hynes RO, Wagner DD. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Cell, 1996, 84:563-74.

Subramaniam M, Frenette PS, Saffaripour S, Hynes RO, Wagner DD. Defects in hemostasis in P-selectin-deficient mice. Blood, 1996, 87:1238-42.

Frenette PS, Johnson RC, Hynes RO, Wagner DD. Platelets roll on activated vascular endothelium in vivo: an interaction mediated by endothelial P-selectin. Proc Natl Acad Sci USA, 1995, 92:7450-4.

Johnson RC, Mayadas TN, Frenette PS, Mebius RE, Subramaniam M, Lacasce A, Hynes RO, Wagner DD. Blood cell dynamics in P-selectin-deficient mice. Blood, 1995, 86:1106-14.

Frenette PS, Desforges JF, Schenkein DP, Rabson A, Slapack CA, Miller KB. Granulocyte-macrophage stimulating factor (GM-CSF) priming in the treatment of elderly patients with acute myelogenous leukemia. Am J Hematol, 1995, 49:48-55.

Frenette PS, Thirlwell MP, Trudeau M, Thomson DMP, Joseph L, Shuster JS. Diagnostic Value of CA 27-29, CA 15-3, Mucin-like carcinoma antigen (MCA), carcinoembryonic antigen (CEA) and CA 19-9 in breast and gastrointestinal malignancies. Tumor Biol, 1994, 15:247-254.

Rennie PS, Bowden JF, Bruchovsky N, Frenette PS, Foekens JA, Cheng H. DNA and protein components of nuclear acceptor sites for androgen receptors in the rat prostate. J Steroid Biochem, 1987, 27:513-20.

Case Report


Frenette PS, Paltiel OB, Hudson T, Newkirk M, Watters AK. Multiple myeloma presenting as migratory panniculitis. Int J Dermatol, 1992, 31:424-5.

Invited Contributions


Méndez-Ferrer S, Frenette PS. Hematopoietic stem cell trafficking: regulated adhesion and attraction to bone marrow microenvironment. Ann N Y Acad Sci. 2007 Nov; 1116:392-413.

Hidalgo A, Frenette PS. Leukocyte Podosomes Sense Their Way through the Endothelium. Immunity. 2007 Jun; 26(6):753-5.

Frenette PS, Atweh GF. Sickle cell disease: old discoveries, new concepts, and future promise. J Clin Invest. 2007 Apr;117 (4):850-8.

Chiang EY, Frenette, PS. Sickle Cell Vaso-Occlusion. Hematol Oncol Clin N AM 19 (2005) 771-784.

Frenette PS. Sickle cell vaso-occlusion: heterotypic, multicellular, aggregations driven by leukocyte adhesion. Microcirculation, 2004, 11:167-177.

Frenette PS. P-selectin and VWF tie the knot. Blood, 2004, 103:1979-1980.

Frenette PS. Phages that display P-selectin antagonism. Blood, 2002, 100:3443-4.

Frenette PS. Sickle cell vaso-occlusion: multistep and multicellular paradigm. Curr Opin Hematol, 2002, 9:101-106.

Frenette PS. Locking a leukocyte integrin with statins. New Eng J Med, 2001, 345:1419-1421.

Denis CV, Frenette PS. Plaquette et endothelium: un mariage de raison. Médecine Sciences (French), 2001, 17:252-255.

Frenette PS, Wagner DD. Insights into selectin function from knockout mice. Thromb Haemost, 1997, 78:60-64.

Frenette PS, Wagner DD. Adhesion molecules- Part II: Blood vessels and blood cells. New Eng J Med, 1996, 335:43-45.

Frenette PS, Wagner DD. Adhesion molecules- Part I. New Eng J Med, 1996, 334:1526-1529.