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Research

Publications: 2002 - Present

Méndez-Ferrer S, Lucas D, Battista M, Frenette PS. Haematopoietic stem cell release is regulated by circadian oscillations. Nature 452, 442-447 (27 March 2008).

Méndez-Ferrer S, Frenette PS. Hematopoietic stem cell trafficking: regulated adhesion and attraction to bone marrow microenvironment. Ann N Y Acad Sci. 2007 Nov; 1116:392-413.

Chang J, Shi PA, Chiang EY, Frenette PS. Intravenous immunoglobulins reverse acute vaso-occlusive crises in sickle cell mice through rapid inhibition of neutrophil adhesion. Blood. 2008 Jan 15; 111(2):915-23. Epub 2007 Oct 11.

Hidalgo A, Frenette PS. Leukocyte Podosomes Sense Their Way through the Endothelium. Immunity. 2007 Jun; 26(6):753-5.

Hidalgo A, Peired AJ, Wild MK, Vestweber D, Frenette PS. Complete Identification of E-Selectin Ligands on Neutrophils Reveals Distinct Functions of PSGL-1, ESL-1, and CD44. Immunity, 2007, 26(4):477-89.

Frenette PS, Atweh GF. Sickle cell disease: old discoveries, new concepts, and future promise. J Clin Invest. 2007 Apr;117(4):850-8.

Chiang EY, Hidalgo A, Chang J, Frenette PS. Imaging receptor microdomains on leukocyte subsets in live mice. Nat Methods. 2007 Mar;4(3):219-22.

Katayama Y, Battista M, Kao W, Hidalgo A, Peired A, Thomas SA, Frenette, PS. Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow. Cell 2006 124: 407-421.

Bogunovic M, Ginhoux F, Wagers A, Loubeau M, Isola LM, Lubrano L, Najfeld V, Phelps RG, Grosskreutz C, Scigliano E, Frenette PS, and Merad M. Identification of a cycling and radio-resistant dendritic cell population in mouse and human dermis: potential impact on graft versus host disease. J. Exp. Med. 2006 Nov 27;203(12):2627-38.

Angeli V, Ginhoux F, Llodra J, Quemeneur L, Frenette PS, Skobe M, Jessberger R, Merad M, Randolph GJ. B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity. 2006 Feb;24(2):203-15.

Chiang EY, Frenette, PS. Sickle Cell Vaso-Occlusion. Hematol Oncol Clin North Am 2005, 19:771-784.

Hidalgo A, Frenette PS. Enforced fucosylation of neonatal CD34+ cells generates selectin ligands that enhance the initial interactions with microvessels but not homing to bone marrow. Blood, 2005, 105:567-75.

Katayama Y, Hidalgo A, Chang J, Peired A, Frenette PS. CD44 is a physiological E-selectin ligand on neutrophils. J Exp Med, 2005, 201:1183-9.

Katayama Y, Hidalgo A, Peired A, Frenette PS. Integrin alpha4beta7 and its counterreceptor MAdCAM-1 contribute to hematopoietic progenitor recruitment into bone marrow following transplantation. Blood, 2004, 104:2020-6.

Hidalgo A, Peired AJ, Weiss LA, Katayama Y, Frenette PS. The integrin αMβ2 anchors hematopoietic progenitors in the bone marrow during enforced mobilization. Blood, 2004, 104:993-1001.

Turhan A, Jenab P, Bruhns P, Ravetch JV, Coller BS, Frenette PS. Intravenous immune globulin prevents venular vaso-occlusion in sickle cell mice by inhibiting leukocyte adhesion and the interactions between sickle erythrocytes and adherent leukocytes. Blood, 2004, 103:2397-400.

Frenette PS. Sickle cell vaso-occlusion: heterotypic, multicellular, aggregations driven by leukocyte adhesion. Microcirculation, 2004, 11:167-177.

Frenette PS. P-selectin and VWF tie the knot. Blood, 2004, 103:1979-1980.

Martin AP, Coronel EC, Sano G, Chen S, Vassileva G, Canasto-Chibuque C, Sedgwick JD, Frenette PS, Lipp M, Furtado GC, and Lira SA. A Novel Model for Lymphocytic Infiltration of the Thyroid Gland Generated by Transgenic Expression of the Chemokine CC Chemokine Ligand 21. J. Immunol. 2004 Oct 15;173(8):4791-8.

Frenette J, Chbinou N, Godbout C, Marsolais D, Frenette PS. Macrophage, not neutrophil, infiltrates skeletal muscle in mice deficient in P/E selectin following mechanical reloading. Am J Physiol, 2003, 285:R727-32.

Katayama Y., Furie BC, Vestweber D, Furie B, Frenette PS. PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: Evidence for cooperation between E-selectin ligands and α4 integrin. Blood, 2003, 102:2060-2067.

Katayama Y, Frenette PS. Galactocerebrosides are required postnatally for stromal-dependent bone marrow lymphopoiesis. Immunity, 2003, 18:789-800.

Hidalgo A, Ma, S, Peired A, Weiss LA, Cunningham-Rundles C, Frenette PS. Insights into leukocyte adhesion deficiency type II from a novel mutation in the GDP-fucose transporter gene. Blood, 2003, 101: 1705-1712.

Hidalgo A, Weiss LA, Frenette PS. Functional selectin ligands mediating human CD34+ cell interactions with bone marrow endothelium are enhanced postnatally. J Clin Invest, 2002, 110:559-569.

Turhan A., Weiss LA, Mohandas N, Coller BS, Frenette PS. Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm. Proc Natl Acad Sci USA, 2002, 99:3047-3051.

Frenette PS. Phages that display P-selectin antagonism. Blood, 2002, 100:3443-4.

Frenette PS. Sickle cell vaso-occlusion: multistep and multicellular paradigm. Curr Opin Hematol, 2002, 9:101-106.