Publications

2013

Faraco J*, Lin L*, Kornum B, Kenny EE, Trynka G, Einen M,Rico T, Lichtner P, Arnulf I, Dauvilliers Y, Lecendreux M, Javidi S, Geisler P, Mayer G, Pizza F, Poli F, Plazzi G, Overeem S, Gert S, Lammers J, Kemlink D, Sonka K, Nevsimalova S, Rouleau G, Desautels A, Montplaisir J, Hor H, Frauscher B, Ehrmann L, Högl B, Jennum P, Bourgin P, Chen W, Concannon P,Thompson S, Damotte V, Fontaine B, Breban M, Gieger C, Klopp N, Deloukas P, Wijmenga C, Hallmayer J, Onengut-Gumuscu S, Rich SS, Winkelmann J and Mignot E. ImmunoChip study implicates antigen presentation to T cells in narcolepsy. (2013) PLoS Genet (accepted)

Fu W, O'Connor TD, Jun G, Kang HM, Abecasis G, Leal SM, Gabriel S, Altshuler D, Shendure J, Nickerson DA, Bamshad MJ; NHLBI Exome Sequencing Project, Akey JM. Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. (2013) Nature 493(7431):216-20

2012

McVean and the 1000 Genomes Project Consortium (2012) An integrated map of genetic variation from 1,092 human genomes. (2012) Nature 491(7422):56-65 [PubMed]

Boileau C, Guo DC, Hanna N, Regalado ES, Detaint D, Gong L, Varret M, Prakash SK, Li AH, d'Indy H, Braverman AC, Grandchamp B, Kwartler CS, Gouya L, Santos-Cortez RL, Abifadel M, Leal SM, Muti C, Shendure J, Gross MS, Rieder MJ, Vahanian A, Nickerson DA, Michel JB; National Heart, Lung, and Blood Institute (NHLBI) Go Exome Sequencing Project, Jondeau G, Milewicz DM. TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome. Nat Genet. 2012 Jul 8;44(8):916-21

Emond MJ, Louie T, Emerson J, Zhao W, Mathias RA, Knowles MR, Wright FA, Rieder MJ, Tabor HK, Nickerson DA, Barnes KC; National Heart, Lung, and Blood Institute (NHLBI) GO Exome Sequencing Project; Lung GO, Gibson RL, Bamshad MJ. Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis. Nat Genet. 2012 Jul 8;44(8):886-9

Tennessen JA*, Bigham AW*, O’Connor TD*, Fu W, Kenny EE, Gravel S, McGee S, Do R, Liu X, Jun G, Kang HM, Jordan D, Leal SM, Gabriel S, Rieder MJ, Abecasis G, Altshuler D, Nickerson DA, Boerwinkle E, Sunyaev S, Bustamante CD, Bamshad MJ, Akey JM, BroadGO, SeattleGO, on behalf of the NHLBI Exome Sequencing Project (2012) Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science 337 6090;64-9 [PubMed]

Kenny EE*, Timpson N*, Sikora M, Yee MC, Moreno AE, Stoneking M, Bustamante CD and Myles S (2012) Melanesian blond hair caused by a radical amino acid change in TYRP1 Science 336(6081):554 [Pubmed]

Kenny EE, Atzmon G, Bergman A, Chowders J, Darvasi A, Desnick JR, Eliakim R, Erazo M, Gregersen P, Hakonarson H, Karban A, Mayer L, McGovern D, Mitchell A, Mulle J, Ostrer H, Ozelius L, Pulver A, Ullman T, Waterman M, Pe’er I, Peters I and Cho J (2012) Genome-wide scan of Ashkenazi Jewish Crohn’s Disease suggest novel susceptibility loci unique to this population PLoS Genet, 8(3);e1002559 [PubMed][Free Text]

2011

Gusev A, Shah MJ, Kenny EE, Ramachandran A, Lowe JK, Salit J, Lee C, Hansen S, Joseph E, Levandowsky E, Pearlstein K, Weaver T, Quynh D, Peckham H, McLaughlin S, Lyons M, Sheth V, Stoffel M, Friedman JM, Breslow JL and Pe’er I (2011) Low-pass genomewide sequencing and variant imputation using identity-by-descent in an isolated human population Genetics, 190(2):679-89 [PubMed]

Kenny EE and Bustamante CD (2011) SnapShot: human biomedical genomics Cell 147(1): 248 [PubMed]

Gusev A, Kenny EE, Lowe JK, Salit J, Saxena R, Kathiresan S, Altshuler DM, Friedman JM, Breslow JL, Pe’er I.  (2011) DASH: A method for IBD-based haplotype discovery uncovers association to recent variation.  Amer J of Hum Genet 88(6):706-17 [PubMed][Free Text]

Kenny EE, Kim M, Gusev A, Lowe JK, Salit J, Smith JG, Kovvali S, Min Kang H, Newton-Cheh C, Daly M, Stoffel M, Altshuler DM, Friedman JM, Eskin E, Breslow JL and Pe’er I (2011) Increased power of mixed-models facilitates association mapping of 10 loci for metabolic traits in an isolated population Hum Mol Genet 20(4):827-39 [PubMed][Free Text]

2010

Kenny EE. Genome-scale genetics: lessons from founder populations. (2010) Ph.D. Thesis, The Rockefeller University [Free Text]

2009

Kenny EE, Gusev A, Riegel K, Lütjohann D, Lowe JK, Salit J, Maller JB, Stoffel M, Daly MJ, Altshuler DM, Friedman JM, Breslow JL, Pe’er I and Sehayek E (2009) Systematic haplotype analysis resolves a complex locus affecting plasma plant sterol levels in a Micronesian Island population Proc Natl Acad Sci 106(33):13886-91[PubMed][Free Text]

Lowe JK, Maller JB, Pe’er I, Neale BM, Salit J, Kenny EE, Shea JL, Burkhardt R, Ji W, Noel M, Nee Foo J,  Blundell ML, Garcia L, Sullivan ML, Lee HE, Utterman A, Ferdowsian H, Lifton RP, Breslow JL, Stoffel M,  Daly MJ, Altshuler DM, Friedman JM (2009) Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae PLoS Genet 5(2):31000365 [PubMed][Free Text]

Burkhardt R, Kenny EE and Breslow JL (2009) Genome-wide associations and lipid risk factors Current Cardiovascular Lipid Reports 3(1):12-17 [Available on request]

2008 and earlier

Burkhardt R, Kenny EE, Lowe JK, Birkeland A, Josowitz R, Noel M, Salit J, Maller JB, Pe’er I, Daly MJ, Altshuler D, Stoffel M, Friedman JM and Breslow JL (2008) Common SNPs in HMGCR in Micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon 13 ATVB28:11 2078-84 [PubMed][Free Text]

Schwarz EM, Antoshechkin I, Bastiani C, Bieri T, Blasiar D, Canaran P, Chan J, Chen CK, Chen N, Chen WJ, Davis P, Fiedler TJ, Girard L, Harris TW, Kenny EE, Kishore R, Lawson D, Lee R, Müller HM, Nakamura C, Ozersky P, Petcherski A, Rogers A, Spooner W, Tuli MA, Van Auken K, Wang Q, Durbin R, Spieth J, Stein LD, Sternberg PW (2006) Wormbase: better software, richer content. Nucleic Acids Res 1:34 Database issue; D475-8

Chen N, Harris TW, Antoshechkin I, Bastiani C, Bieri T, Blasiar D, Bradnam K, Canaran P, Chan J, Chen CK, Chen WJ, Davis P, Kenny E, Kishore R, Lawson D, Lee R, Müller HM, Nakamura C, Ozersky P, Petcherski A, Rogers A, Sabo A, Schwarz EM, Van Auken K, Wang Q, Durbin R, Spieth J, Sternberg PW, Stein LD (2005) Wormbase: a comprehensive data resource for Caenorhabditis biology and genomics. Nucleic Acids Res. 1:33 Database issue; D383-9

Müller HM, Kenny EE, Sternberg PW (2004) Textpresso: an ontology-based information retrieval and extraction system for biological literature PLoS Biol 2(11); e309

Harris TW, Chen N, Cunningham F, Tello-Ruiz M, Antoshechkin I, Bastiani C, Bieri T, Blasiar D, Bradnam K, Chan J, Chen CK, Chen WJ, Davis P, Kenny E, Kishore R, Lawson D, Lee R, Müller HM, Nakamura C, Ozersky P, Petcherski A, Rogers A, Sabo A, Schwarz EM, Van Auken K, Wang Q, Durbin R, Spieth J, Sternberg PW, Stein LD (2004) Wormbase: a multi-species resource for nematode biology and genomics. Nucleic Acids Res. 1:32 Database issue; D411-7

Harris TW, Lee R, Schwarz EM, Bradnam K, Lawson D, Chen W, Chen N, Blasiar D, Kenny E, Cunningham F,  Kishore R, Chan J, Muller HM,  Petcherski A, Thorisson G, Day A, Bieri T, Rogers A, Chen CK,  Durbin R, Spieth J, Sternberg PW, Stein LD (2003) Wormbase: a cross-species database for comparative genomics. Nucleic Acids Res 1:31(1):133-7

Mayer C, Köher C, Kenny E, Prusko C, RajBhandary UL (2003) Initiator tRNA: effects of overproduction of aminoacyl-tRNA synthetases, methionyl-tRNA formyltransferase and initiation factor 2 on activity in initiation. Biochemistry 42(17):4787-99


* indicates co-authorship