Personal Genome Analysis

I am the course director for Mount Sinai’s personal genome analysis course sequence

  1. BSR2401: Introduction to Human Genome Analysis
  2. BSR6402: Practical Analysis of Your Personal Genome

These first-of-their-kind courses were first taught in 2012 and have been discussed in many settings. The course and the results from a companion research study, “Personal Genomes in the Classroom Setting”, are described in the following publications:

Linderman MD, Bashir A, Diaz GA, Kasarskis A, Sanderson SC, Zinberg RE, et al. Preparing the next generation of genomicists: a laboratory-style course in medical genomics. BMC Med Genomics. 2015;8:47.

Sanderson SC, Linderman MD, Zinberg R, Bashir A, Kasarskis A, Zweig M, Suckiel S, Shah H, Mahajan M, Diaz GA, Schadt EE. How Do Students React to Analyzing Their Own Genomes in a Whole-Genome Sequencing Course?: Outcomes of a Longitudinal Cohort Study. Genetics in Medicine. 2015.

Sanderson SC, Linderman MD, Kasarskis A, Bashir A, Diaz GA, Mahajan M, Shah H, Wasserstein M, Zinberg RE, Zweig M, Schadt EE. Informed decision-making among students analyzing their personal genomes on a whole genome sequencing course: a longitudinal cohort study. Genome Med. 2013 Dec 30;5(12):113.

BRS2401: Introduction to Human Genome Analysis

Students in this hands-on laboratory-style workshop will analyze a publicly available whole human exome/genome, starting with raw sequencer output through clinical interpretation. Students will be introduced to the ethical, legal and social implications (ELSI) of personal genomics, the techniques and technologies for sequence analysis and the process of communicating those analyses to patients. This course is intended to provide an introduction to human genome sequencing for genetics professionals and trainees. At the conclusion of the class students will have the necessary background to make an informed decision about personal whole exome/genome sequencing.

This course serves the entire Mount Sinai community. The May 2015 iteration had 35 participants, including graduate students, medical students, genetic counseling students, post-docs, laboratory fellows, laboratory geneticists, nurses and junior faculty, from many different departments.

BSR6402: Practical Analysis of Your Personal Genome

Students in this course will analyze a human genome sequence starting with raw sequence reads through identifying a list of sequence variants. Using public databases, literature and other resources students will formulate hypotheses about the phenotypic significance of these variants. This is a hands-on, laboratory course in which students will choose to analyze either their own genome or a reference genome after lectures and counseling to make the consequences of personal genome analysis clear.

Economic Value of Genomic Information

I am the co-director along with Geoffrey Smith of

  1. DTE Makers Studio II - Pharmacogenomics

DTE Makers Studio II - Pharmacogenomics

DTE Makers Studio II – Pharmacogenomics is a semester-long studio course designed to explore the value of the human genome through the creation of quantitative models of the value of genetic information in the context of pharmacogenomics.