Friday June 24th

Icahn School of Medicine at Mount Sinai - Hess Building - Davis Auditorium - 1470 Madison Ave, New York

2016

Sanofi – MSISB Mount Sinai Systems Pharmacology Symposium

SYmposium Description

Significant advances in data measurement technologies and capabilities, and advancements in computing, are transforming the biological and clinical sciences into data and computational sciences. These opportunities in leveraging computational and data sciences can be harnessed, as biological and clinical knowledge of disease and drug perturbations to a healthy homeostatic biome can be translated into mathematical equations and computer models. With the appropriate investment in the computational sciences, these computer models can be subsequently used for both in silico drug discovery (e.g. identification of novel targets) and computer-enabled drug development (e.g. virtual clinical trials). The field of systems pharmacology seeks to: (1) leverage novel measurement technologies to enhance our capture of the biology at multiple scales; and (2) subsequently integrate these data and biological inputs into mechanistic computational models that facilitate the development of novel therapeutics. Realizing the full potential of systems pharmacology, however, will require productive and innovative collaborations between academic researchers and scientists working in the pharmaceutical industry. Accordingly, this symposium will bring together local and national experts from academia and industry in order to:

The speakers presenting at this symposium are established experts in systems pharmacology representing both academic and industrial research. However, we strongly encourage participation from emerging investigators and trainees, in particular during the poster session.

Friday June 24th, 2016

Icahn School of Medicine at Mount Sinai - 1470 Madison Ave, New York
Sanofi – MSISB Mount Sinai Systems Pharmacology Symposium

Agenda

TIME

SPEAKER

TITLE

8:00 a.m.   Registration & Continental Breakfast
8:45 a.m. Karim Azer - Sanofi
Eric Sobie - ISMMS
Introductory Remarks
9:00 a.m.
Yoram Rudy
Washington University
Multi-Scale Modelling and Imaging Cardiac Electrophysiology: A Potential Approach for Drug Developmentand Evaluation
9:50 a.m. Eric Sobie - ISMMS Exploiting mathematical models to predict differences between individuals in the response to anti-arrhythmic and pro-arrhythmic drugs
10:25 a.m.   Networking Coffee Break
10:45 a.m. Fei Hua- Pfizer Development and clinical application of the coagulation systems model
11:20 a.m. Karim Azer - Sanofi Extending the Value of Disease Knowledge and Clinical Data using QSP: A PCSK9 Case-study
11:55 a.m. Nitin Mehrotra - FDA Quantitative system pharmacology: Current state and future considerations
12:30 p.m.   Lunch
1:45 p.m. Melissa Hallow
University of Georgia
Application of a QSP model of the kidney to understand renal effects of SGLT2 inhibition in diabetic kidney disease.
2:20 p.m.   Post Session
3:30 p.m. Dean Bottino - Takeda QSP modeling of antibody-dependent cell-mediated cytotoxicity (ADCC) to guide scheduling of an ADCC-enhanced monoclonal antibody directed against solid tumors
4:10 p.m. Elsje Pienaar
University of Michigan
Multi-Scale Systems Pharmacology Analysis Of Combination Therapy And Drug Resistance In Tuberculosis
4:50 p.m. Karim Azer - Sanofi
Eric Sobie - ISMMS
Closing Remarks
5:00 p.m.   Adjourn

SPEAKERS

Yoram Rudy

KEYNOTE SPEAKER

Multi-Scale Modelling and Imaging Cardiac Electrophysiology: A Potential Approach for Drug Development and Evaluation

Nitin Mehrotra (FDA)

Quantitative system pharmacology: Current state and future considerations

Elsje Pienaar

Multi-Scale Systems Pharmacology Analysis Of Combination Therapy And Drug Resistance In Tuberculosis

Karim Azer

Extending the Value of Disease Knowledge and Clinical Data using QSP: A PCSK9 Case-study

Fei Hua

How do treatments affect coagulation? Systems modeling generates novel predictions

Eric Sobie

Exploiting mathematical models to predict differences between individuals in the response to anti-arrhythmic and pro-arrhythmic drugs

Dean Bottino

QSP modeling of antibody-dependent cell-mediated cytotoxicity (ADCC) to guide scheduling of an ADCC-enhanced monoclonal antibody directed against solid tumors

Melissa Hallow

Modeling cardiac and metabolic diseases: experiences in academia and Big Pharma

Registration

Prices:

Academy: $65.00

Industry: $85.00

Students and postdocs: Free

Abstract Submission

Requirements

All symposium attendees are encouraged to submit abstracts of work to be presented during the poster session. Students and postdoctoral fellows are especially encouraged to take advantage of this opportunity to present their research to leading investigators in academia and the pharmaceutical industry.

Abstracts should adhere to the following format:

Please submit your abstract to :

Pedro Martinez

Abstract submission

Hotels around the area:

Hotel Wales
1295 Madison Ave New York, New York, 10128 (212)876-6000
Website

Courtyard Marriott Hotel 410 East 92nd Street & First Avenue (212)410-6777
Website

Contact the organizers

Dr. Eric Sobie

Eric Sobie

Lead Organizer

 Dr. Karim Azer

Karim Azer

Lead Organizer

Trdy Dilon

Trudy Dillon

Lead organizer

https://www.google.com/maps/dir/40.7906873,-73.9515981/mount+sinai+hess+building/@40.7908823,-73.9867887,13z/data=!4m8!4m7!1m0!1m5!1m1!1s0x89c2f61d91e4ba81:0x3e224256e121c400!2m2!1d-73.9517693!2d40.7908226