We are part of the Black Family Stem Cell Institute (BFSCI) and the Department of Developmental and Regenerative Biology (DRB) and Department of Dermatology at Icahn School of Medicine at Mount Sinai (ISMMS).
Our lab studies the formation and function of stem cell niches. Specifically, we utilize genetic mouse models for embryonic hair follicle formation and for adult hair growth and regeneration to uncover how specialized Dermal Papilla (DP) cells act as instructive niche cells for hair follicle stem cells. A major focus is also to define how DP cells acquire the hair-inducing cell fate in the first place that sets them apart from regular skin fibroblasts. Insights from these studies will reveal general mechanisms on how stem cell niches function and provide a platform for developing hair regenerative therapies.