Swedish Schizophrenia Exome Sequencing Study

Purcell et al. (2014) A polygenic burden of rare disruptive mutations in schizophrenia. Nature.

This site contains data from Purcell et al. (2014), a population-based exome-study of schizophrenia. We have developed a webtool (Genebook) which can be used to browse the result tables and other data (e.g. specific gene-sets used) from that study, integrated with other schizophrenia and bipolar disorder disorder summary results from de novo sequencing studies, copy number variant (CNV) studies and genome-wide association studies (GWAS).

The site also contains data from the parallel Fromer et al. (2014) study, which performed exome sequencing in Bulgarian trios to find de novo mutations that increase the risk of schizophrenia.

If you use these summary results, please cite the references below as appropriate, as well as the references listed in the Genebook (publications tab), as appropriate.

Access Click on the access button to open the Genebook.


Primary references

Fromer et al. (2014) De novo mutations in schizophrenia implicate synaptic networks.

Purcell et al. (2014) A polygenic burden of rare disruptive mutations in schizophrenia.