Aging, why and how

Human age as the consequence of combined force of the mighty nature and the way how we are genetically coded. As the main goal of our genetic code is to construct us to reproduce, keeping us in good shape afterwards is never the intension. Aging can be defined at molecular level by measuring various changes associated with aging, such as gene expression, DNA methylation, protein expressions, etc. Having this comphrehensive molecular picture of human aging is important and can help biomarker discovery, systems modelings, cross-species comparison, and drug development.

Systems geroscience

How does aging contribute to the development of age-related diseases? We consider the interplay of aging and age-related diseases can be best captured by a network modeling, which allows us to consider hundreds or even thousands of processes involved in aging and examing their connections with various diseases. This global view and the corresponding systems approach can help us to prioritize the key pathways driving aging and diseases.

Extend healthspan

People have proven in model organisms that lifespan can be extended by various perturbations. It is unclear if any of these would work in human. Our goal is to develop an in silico predictive model, which is testable in model organisms, so we can predict if a treatment can work in human by applying the model to human aging data.