Hai-Shan Wu

Associate Professor 

Department of Pathology

Mount Sinai School of Medicine

One Gustave L. Levy Place

New York, NY 10029, USA

Phone: (212)241-0468

E-mail: haishan.wu@mssm.edu



Journal Publications:


[70]. Hai-Shan Wu, and Steven Dikman,

“Segmentation of glomerular basement membranes from electron microscopy images,”

Journal of Electron Microscopy, accepted.


[69]. Hai-Shan Wu, Liane Deligdisch, Maria Isabel Fiel, Thomas Schiano, and Joan Gil,

Image segmentation of secondary septa in lungs,”

Journal of Imaging Science & Technology, accepted.


[68]. Hai-Shan Wu, Jacinta Murray, Susan Morgello, Maria Isabel Fiel, Thomas Schiano, Tamara Kalir, Liane Deligdisch, & Joan Gil,

“Restoration of distorted color microscopic images from transverse chromatic aberration of imperfect lenses,”

Journal of Microscopy, accepted.


[67]. Hai-Shan Wu, M. Isabel Fiel, Thomas D. Schiano, Marie Ramer, David Burstein, and Joan Gil,

“Segmentation of textured cell images based on frequency analysis,”

IET Image Processing, accepted. 


[66]. Hai-Shan Wu, Feng-Qian Wang, Yoel Smicun, and David Fishman,

“Recognition of Linear Stress Fibers Based on Hough Transform,”

Analytical and Quantitative Cytology and Histology, accepted. 


[65]. S.-Q. Chen, J.-N. Chen, X.-H. Cai, G.-R. Chen, R.-S. Ge, H.-S. Wu, Z.-L. Lin, J. Lin,

“Perinatal exposure to di-(2-ethylhexyl) phthalate leads to restricted growth and delayed lung maturation in newborn rats,”

Journal of Perinatal Medicine, accepted.


[64]. Sonia Dutta, Feng-Qiang Wang, Hai-Shan Wu, Thayer J. Mukherjee, David A. Fishman,

“The NF-κB and EGFR Pathways Mediate Lysophosphatidic Acid (LPA)-induced VEGF Signaling and Cell Invasion in Epithelial Ovarian Cancer (EOC),”

Gynecologic Oncology, submitted.


[63]. W. J. M. Mulder, M. E. Lobatto, S. Silvera, E. Vucic, C. Calcagno, V. Mani, K. Nicolay, M. Banciu, R. M. Schiffelers, L. van Bloois, H.-S. Wu, J. T. Fallon, J. H. Rudd, V. Fuster, E. A. Fisher, G. Storm, and Z. A. Fayad,

“A glucocorticoid-based nanomedicine as targeted anti-inflammatory treatment for atherosclerosis,”

Science Translational Medicine, submitted.


[62]. Hai-Shan Wu, Steven Dikman, and Joan Gil,

A semi-automatic algorithm for measurement of basement membrane thickness in kidneys in electron microscopy images,”

Computer Methods and Programs in Biomedicine, vol.97, pp.223–231, 2010 .


[61]. Marie Ramer, Hai-Shan Wu, Yael Ramer, Lurmag Orta, Patrick Emanuel, David E. Burstein,

Prognostic value of quantitative p63 immunostaining in adenoid cystic carcinoma (ACC) of salivary gland assessed by computerized image analysis,”

Cancer, vol.116, pp. 77-83, Jan. 2010.


[60]. M. Isabel Fiel, Hai-Shan Wu, Kishore Iyer, Gonzalo Rodriguez-Laiz, Thomas D. Schiano,

 “Rapid Reversal of Parenteral Nutrition-Associated Cirrhosis Following Isolated Intestinal Transplantation,” 
Journal of Gastrointestinal Surgery, vol.13, pp.1717–1723, Sept. 2009. 


[59]. Hai-Shan Wu, Mireille Bitar, David Burstein, Marie Ramer, and Joan Gil,

“An envelope mapping algorithm and its applications in enhancement and segmentation of pancreatic cell images,”

Journal of Imaging Science & Technology, vol.53, No.3, pp.030501-030501-6, May/June, 2009.


[58]. Hai-Shan Wu, Jacinta.Murray, and Susan Morgello,

“ Segmentation of brain immunohistochemistry images using clustering of linear centroids and regional shapes,”

Journal of Imaging Science & Technology, vol.52, No.4, pp.040502-040502-11, July/August, 2008.


[57]. M.I.Fiel , B.Sauter, H.-S. Wu, G. Rodriguez-Laiz, G.Gondolesi, K.Iyer, and T.D.Schiano,

“Regression of hepatic fibrosis after intestinal transplantation in patients with total parenteral nutrition liver disease,”

Clin. Gastroenterol Hepatol., vol.6, No.8, pp.926-933, 2008.         


[56]. Hai-Shan Wu, Maria I. Fiel, T.D. Schiano, and Joan Gil,

“Image segmentation of liver fibrosis,”

Journal of Microscopy, vol.231, Pt.1, pp.70–80, 2008.


[55]. Masayuki Fukata, Anli Chen, Arunan Vamadevan, Ruliang Xu, Hai-Shan Wu and Maria T. Abreu,

Crypt height represents intestinal mucosal barrier function during acute colitis: Correlation with epithelial cell proliferation and apoptosis, in:

Image Analysis in Medical Microscopy and Pathology, (H.-S.Wu & A.J.Einstein, ed.), Signpost, Kerala, pp.107-122, 2007.


[54]. Hai-Shan Wu, Sacha P. Salzberg, and Joan Gil, 
“Automatic image segmentation with linear clustering for quantification of neo-intimal formation after surgical vein grafting,” 
Analytical & Quantitative Cytology Histology, vol.28, No.6, pp. 307-315, Dec. 2006. 


[53]. Hai-Shan Wu, Veneta Hanson, and Joan Gil,

“Estimation of cell count from cell culture images,”

Journal of Imaging Science & Technology, vol.50, pp. 187-192, March/April 2006.


[52]. H.-S. Wu, and J. Gil,

“A biased median filtering algorithm for segmentation of intestinal cell gland images,”

The Scientific World Journal, vol.6, pp.200–220, Feb. 2006.


[51]. Hai-Shan Wu, Ruliang Xu, Noam Harpaz, David Burstein, and Joan Gil,

“Segmentation of intestinal gland images with iterative region growing,”

Journal of Microscopy, vol. 220, Pt 3, pp.190–204, Dec. 2005.


[50]. Hai-Shan Wu, Andrew J. Einstein, Tamara Kalir, Liane Deligdisch, Noam Harpaz, David Burstein, and Joan Gil,

“Image analysis and morphometry in the diagnosis of cancer cells: a review,” in:

Recent Research Developments in Cancer, pp.127-160, 2005.


[49]. Hai-Shan Wu, Ruliang Xu, Noam Harpaz, David Burstein, and Joan Gil,

“Segmentation of microscopic images of small intestinal glands with directional 2-D filters,”

Analytical & Quantitative Cytology Histology, vol.27, pp.291-300, No.5, Oct. 2005.


[48]. E.N.Schachter, G.Skloot, A.Chiarelli, J.Jose, H.Wu, J.Gil, U.Arumugam, S.Bashir, N.Rienzi,

“Early Versus Late Effects of an Anti-Inflammatory Agent in an Asthma Model,”

Amer. J. Respir. Crit. Care Med., vol. 171:A80,  2005.


[47]. Bitar M, Wu H-S, Szporn A, Burstein D, Gil J.

“Fast computerized texture analysis in pancreas cytology without accurate nuclear segmentation,”

Mod. Pathol., 18, supplement 1:326A, 2005.


[46]. L.D. Biertho, C. Kim, H.-S. Wu, P. Unger, and W. B. Inabnet,  

Relationship Between Sestamibi Uptake, Parathyroid Hormone Assay and Nuclear Morphology in Primary Hyperparathyroidism,”

Journal of American College of Surgeons, vol.199,  No.2, pp.229-233, Aug. 2004.  


[45]. Hai-Shan Wu, Liane Deligdisch and Joan Gil,

“Segmentation of microscopic nuclear images-A review,” in:

Recent Res. Devel. Electr., vol.2, ISBN: 81-7895-151-7, Transworld Research Publishing, Kerala, pp.1-18, 2004.


[44]. Hai-Shan Wu, Joan Gil, Liane Deligdisch, and Tamara Kalir,

“Characterization of ovarian nuclei with the parameter of power ratio,”

Microsc. Res. Tech., vol.64, No.4,  pp.287-292, 2004. 

[43]. H.-S. Wu, A. J. Einstein, L. Deligdisch, T. Kalir, and J. Gil,
“Characterization of nuclear images based on analysis of fractional summation systems,”
Fractals, vol.12, No.2,  pp.157-169, 2004.


[42]. H.-S. Wu, J. Gil, and L. Deligdisch,

"Region growing segmentation of chromatin clumps of ovarian cells using adaptive gradients,"

Journal of Imaging Science & Technology, vol.48, No.1, pp.22-27, Jan./Feb. 2004.


[41]. J.Gil, and H.-S. Wu,

"Applications of image analysis to anatomic pathology: realities and promises,"

Cancer Investigation, vol.21, pp.950-959, 2003.


[40]. L.Deligdisch, C.Miranda, H.-S.Wu, and J.Gil,

"Human papillomavirus-related cervical lesions in adolescents: a histologic and morphometric study,"

Gynecologic Oncology, vol.89, pp.52-59, 2003.


[39]. H.-S. Wu, and J. Gil,

"Linear Clustering for Segmentation of Color Microscopic Lung Cell Images,"

Journal of Imaging Science & Technology, vol.47, pp.161-170, Mar./Apr. 2003. 


[38]. J.Gil, H.-S.Wu, and B.Wang,

"Image analysis and morphometry in the diagnosis of breast cancer,"

Micros. Res. Tech., vol.59, pp.109-118, Oct. 2002.


[37]. A.Butler, X.He, R.E.Gordon, H.-S. Wu, S.Gatt, and E.H.Schuchman,

"Reproductive pathology and sperm physiology in acid sphingomyelinase-deficient mice,"

American Journal of Pathology, vol.161, No.3, pp.1061-1075, Sept. 2002.


[36]. D.N.Jourdy, G.S.Skloot, J.Gil, H.Wu, E.N.Schachter,

“The effect of chronic antigen challenge on airway smooth muscle stretch induced relaxation,”

Am. J. Resp. Crit. Care. Med., vol.165, A255, 2002.


[35] A.J.Einstein, H.-S. Wu, and J.Gil,

"Detrended fluctuation analysis of chromatin texture for diagnosis in breast cytology,"

Fractals, vol.10, No.1, pp.19-25, March 2002.


[34] T. Kalir, H. Wu, R. Gordon, and J.Gil,

"Morphometric and electron microscopic analyses of the effect of gonadotropin-releasing hormone agonist treatment on arteriole size in uterine leiomyomas,"

Arch. Pathol. Med., vol.124, pp.1295-1298, Sept. 2000.


[33]. H.-S.Wu, J.Barba, and J.Gil,

"Iterative thresholding for segmentation of cell images,"

Journal of Microscopy, vol. 197, Pt.3, pp.296-304, March 2000.


[32] L.Deligdisch, J.Gil, H.Kerner, H.S.Wu, D.Beck, and R.Gershoni-Baruch,

"Ovarian dysplasia in prophylactic oophorectomy specimens,"

Cancer, vol.86, pp.1544-1550, Oct. 1999.


[31]. H.-S.Wu, J.Gil, R. Jeremiah, and J.Barba,

"Unsupervised learning for segmentation of textured cytologic images,"

IEE Electr. Lett., vol.35, No.8, pp.630-631, Apr. 1999. 


[30]. A.J.Einstein, H.-S.Wu, and J.Gil,

Fractal characterization of chromatin appearance for diagnosis in breast cytology,"

Journal of Pathology, vol.185, pp.366-381, Aug. 1998 


[29]. T.Kalir, M.Goldstein, P.Dottino, M.Brodman, P.Gordon, L.Deligdich, H.Wu, and J.Joan,

"Morphometric and elctron-microscopic analysis of the effects of gonadotropin-releasing hormone agonists on uterine leiomyomas,"

Arch. Pathol. Lab. Med., vol.122, pp.442-446, May 1998.


[28]. H.-S.Wu, and J.Barba,

"Minimum entropy restoration of star field images,"

IEEE Transactions on Systems, Man, and Cybernetics, vol.28, part B, No.2, pp.227-231, April 1998.


[27]. H.-S.Wu, J.Barba, and J.Gil,

"A parametric fitting algorithm for segmentation of cell images,"

IEEE Transactions on Biomedical Engineering, vol.45, No.3, pp.400-407, Mar. 1998.


[26]. H.-S.Wu, J.Gil, and J.Barba, "Optimal segmentation of cell images,"

IEE Proceedings, Vision, Image and Signal Processing, vol.145, No.1, pp.50-56, Feb. 1998.


[25]. A.J.Einstein, H.-S.Wu, and J.Gil,

"Self-affinity and lacunarity of chromatin texture in benign and malignant breast epithelial cell,"

Physical Rev. Lett., vol.80, pp.397-400, Jan. 1998.


[24]. A.J.Einstein, H.-S.Wu, and J.Gil,

Fractal characterization of nuclear texture in breast cytology: frequency and spatial domain approaches, in:

Fractals in Biology and Medicine (G.Losa ed.), Nov. 1997. 


[23]. H.-S.Wu, A.J.Einstein, and J.Gil,

"Fractal characterization of irregularly shaped images by frequency analysis,"

Fractals, vol.5, No.4, pp.665-672, Dec. 1997.


[22]. A.J.Einstein, J.Gil, S.Wallenstein, C.A.Bodian, M.Sanchez, D.E.Burstein, C.Sheppard, H.-S.Wu, and Z.Liu,

"The reproducibility of interactive segmentation procedures for breast cytology,"

Journal of Microscopy, vol.188, Pt.2, pp.136-148, Nov. 1997.


[21]. H.-S.Wu, R.A.King, J.Barba, and J.Gil,

"DCT basis decomposition coding for biomedical X-ray images using vector quantization,"

Journal of Imaging Science and Technology, vol.41, pp.160-167, March 1997.


[20]. H.-S.Wu, and J.Barba, J.Gil,

"A focusing algorithm for high magnification cell imaging,"

Journal of Microscopy, vol.184, pt.2, pp.133-142, Nov. 1996.  


[19]. H.-S.Wu, and J.Barba, J.Gil,

"An iterative algorithm for cell segmentation using short-time Fourier transform,"

Journal of Microscopy, vol.184, pt.2, pp.127-132, Nov. 1996. 


[18]. H.-S.Wu, and J.Barba, J.Gil,

"Region growing segmentation of textured cell images,"

IEE Electr. Lett., vol.32, pp.1084-1085, June 1996. 


[17]. H.-S.Wu, J.Barba, and J.Gil,

"Morphological segmentation of textured cell images,"

Journal of Imaging Science and Technology, vol.40, pp.265-270, May 1996. 


[16]. H.-S.Wu, and J.Barba,

"An efficient semi-automatic algorithm for cell contour extraction,"

Journal of Microscopy, vol.179, pt.3, pp.270-276, Sept. 1995.


[15]. H.-S.Wu, and J.Barba,

"A classified algorithm for segmentation of multispectral images,"

Journal of Imaging Science and Technology, vol.39, pp.26-30, Jan. 1995.


[14]. J.Xia, F.Qi, W.Yuan, D.Wang, W.Qiu, Y.Sun, Y.Huang, G.Shen, H.Wu, 
"Computer Aided Simulation System 
for Orthognathic Surgery," 
Proc. IEEE Symp. Computer-Based Medical Systems, pp.237-240, 1995.  


[13]. H.-S.Wu, and J.Barba,

"An Algorithm for Noisy Cell Contour Extraction via Area Merging,"

Journal of Imaging Science and Technology, vol.38, pp.604-607, Nov 1994.


[12]. H.-S.Wu, and J.Barba,

"Coding of quadtree structure using run-length code,"

IEE Electr. Lett., vol.29, pp.1741-1742, Sept. 1993.


[11].  H.-S.Wu,

"Minimum entropy deconvolution of images,"

Journal of China Institute of Communications, vol.14, No.4, pp.88-94, July 1993.


[10].  H.-S.Wu, and J.Barba,

"Index allocation in vector quantization for noisy channels,"

IEE Electr. Lett., vol.29, pp.1317-1319, July 1993.


[9]. H.-S.Wu, R.A.King and R.I.Kitney,

"Improving the performance of the quadtree-based image approximation via the generalized DCT,"

IEE Electr. Lett., vol.29, pp.887-888, May 1993.


[8]. F.-H.Qi, and H.-S.Wu,

"Real-time image filtering using the pipelines,"

Journal of Infrared and Millimeter Waves, vol.12, pp.52-56, Feb. 1993.


[7].  H.-S.Wu, and X.H.Gu,

"Hexagonal discrete coding transform image coding,"

Journal of Shanghai Jiaotong University, vol.27, No.1, pp.80-87, Jan. 1993.


[6]. K.Xin, and H.-S.Wu,

"Low-rate interpolation image coding,"

Journal of Shanghai Jiaotong University, vol.26, No.3, pp.10-16, May 1992.


[5]. H.-S.Wu,

"Blind image restoration for zero-phase blurs,"

Journal of Imaging Science and Technology, vol.36, pp.206-208, Mar. 1992.


[4]. H.-S.Wu,

"A fast search algorithm for vector quantization,"

IEE Electr. Lett., vol.28, pp.457-458, Feb. 1992.


[3]. H.-S.Wu,

"Hexagonal discrete cosine transform for image coding,"

IEE Electr. Lett., vol.27, pp.781-783, Apr.1991.


[2]. H.-S.Wu,

"Minimum entropy deconvolution for restoration of blurred two-tone images,"

IEE Electr. Lett., vol.26, pp.1183-1184, July 1990.


[1]. F.-N.Ku, and H.-S.Wu,

"Edge detection with a filter concentrating the energy,"

Journal of China Institute of Communications, vol.7, pp.85-91, Nov.1986.




[1]. Hai-Shan Wu & Andrew Einstein, (ed.),
Image Analysis in Medical Microscopy and Pathology,
Signpost, Kerala, 2007.