Research Portal

The Aaronson laboratory is involved in cancer gene discovery and function with the goal of identifying novel targets for therapy

HIV-related opportunistic infections, vaccine response, and complications of HIV disease, including studies of the pathogenesis of inflammation that contributes to the co-morbidities associated with the aging of those with HIV infection.

The goal of our research is to better understand the effects of chronic metabolic diseases, such as diabetes, on brain function. Given the high utilization of energy by the brain, we aim to explore the implications of altered metabolism at the behavioral, circuit, cellular and molecular levels. Currently, we use animal models of diabetes to identify the ways in which long-term exposure to hyperglycemia can lead to increased susceptibility to stress and to addiction- or depression- or anxiety-like syndromes.

Translating genomic medicine into clinical care

The Advanced Wearable Sensors and Electronics Lab employs a wide range of emerging materials and tools, including soft materials, micromachining, and stretchable electronics, to design and fabricate soft electronic devices compatible for safe and comfortable integration with human body. Our mission is to develop next generation wearable systems capable to generate high-fidelity ambulatory health data as well as to deploy the new sensor technologies in clinical research and patient care.

Investigating arrhythmia mechanisms in structural heart disease at multiple levels of integration

Exploring the genome within human brain cell nuclei, including potential alterations in psychiatric diseases

Studying the role of leukocytes with emphasis on T cells in the development of autoimmune diseases and chronic inflammation

Hepatitis C virus, development of hepatocellular carcinoma (liver cancer), and the immunobiology of the human liver

The Bowcock lab investigates the genetic differences or spontaneous changes in genes that lead to disease and are interested in understanding the genetic basis disease and cancer.

Focusing on translational research modeling disordered eating behaviors, as well as drug use

Systems Bioengineering Lab studies cellular mechanobiology using combination of multi-omics technologies, quantitative microscopy, and tissue engineering methods

Researching transcription regulation; coding/non-coding RNA biology; and genome architecture, particularly within infectious disease

How HIV promotes liver inflammation and fibrosis through interactions with both activated hepatic stellate cells (HSCs) and liver macrophages (Kupffer cells)

Researching hematopoietic and vascular development in mice; regulation of stem cell proliferation, survival, and differentiation; gene regulation; primitive and definitive endodermal lineages; and angiogenesis

Investigating various complications in genomic architecture

Investigating the molecular determinants of virulence of emerging viruses, focusing on the pathogenic Ebola and Marburg viruses

Using animal models to establish causal links between manipulations of defined neural circuits, behavioral and cognitive functions

Description Focusing on mechanism of RNA processing, particularly messenger RNA decay in gram-positive bacterium

Exploring complex cellular and molecular interactions promoting viral replication and immune cell depletion in HIV

Investigating mechanisms required to generate normal functioning neural circuits

The Berin Laboratory studies the immune basis of food allergy and early life susceptibility to allergic disease. We use high dimensional immune profiling in partnership with clinical trials to identify mechanisms of food allergy and tolerance.

Our focus is on epigenetic regulation of gene expression in multiple biological pathways including cancer, cellular senescence and stem cell biology

Focusing on combining fundamental research in dendritic cell biology with innovative translational and clinical approaches

Researching transcriptional regulation of red-cell-specific gene expression

Leveraging human genetic studies and single-cell RNA sequencing of patient samples to uncover the mechanism of NASH and atherosclerosis.

The Blenkinsop lab works on the transcriptional and epigenetic foundations of retina regeneration and plasticity. We are currently focused on the retinal pigment epithelium (RPE) and RPE related diseases. Our approach is to develop in vitro models of disease using human donor tissue. We are also developing cellular transplantation therapies to replace damaged or lost cells in eye disease

Investigating human immune system using immunogenomic, molecular biology, cellular biology, immunology and clinical tools

Measuring long-term lead exposure via non-invasive x-ray fluorescence

Researching viral factors in respiratory influenza transmission

Research in our lab aims to identify functional and targetable mechanisms underlying disorders affecting early childhood development, particularly autism spectrum disorder and related neurodevelopmental and neuropsychiatric disorders. We are specifically focused on two mechanistic-domains: 1) A-to-I RNA editing in the brain; and 2) immune mechanisms in the blood. Our research program combines functional genomics, computational biology, molecular biology and immunology methods.

The Kim Lab has unique expertise in basic approaches and techniques in innate immunity, neuroimmunology, and behavioral modelling of chronic itch. Additionally, we actively design translational, clinical research studies, and interventional clinical trials.

The Brody Lab studies novel approaches to initiate and increase adaptive immune responses against cancer. These include combinations of checkpoint blockade approaches, discovery of novel tumor immune evasion checkpoints, in situ vaccine strategies using Flt3L to mobilize dendritic cells (DC), cytotoxic therapy to induce immunogenic cell death and load DC with tumor-associated antigens, and DC activators such as TLR and other PRR agonists. A primary focus is on strategies with potential for near-term translation to the clinic, with an emphasis on lymphoid malignancies including lymphoma and CLL.

Exploring microRNA biology; biotechnology; immunology; gene therapy; autoimmune disease; and molecular regulation

His research is aimed at a better understanding of the tumor immunobiology in cutaneous lymphomas, and to develop better treatment modalities for this patient population.

Conducting research addressing the challenges of traumatic spinal cord injury, or SCI

Brain control of metabolism and innate immunity

Integrative genomics of asthma and allergic disorders

The laboratory of Molecular Neuropsychiatry studies human psychiatric and neurological diseases using the methods of genetics, genomics, cell and molecular biology and animal models. Current laboratory focus includes autism, schizophrenia and Alzheimer's disease.

Undertaking a genetic and drug screening approach to target cancer and diabetes, using the Drosophila fruit fly

Our research program has been focused on studying the regulation of brain phospholipid composition and metabolism in Alzheimer's disease (AD) pathogenesis. Using transgenic animal models and postmortem human brain tissue, we investigate the molecular and cellular mechanisms underlying disease development and progression, with the goal of developing novel therapeutic strategies for AD.

Defining novel mediators of kidney podocyte injury and survival in the quest for targeted therapeutics in glomerular disease.

Researching safer and more effective cancer treatments

Our overall goal is to develop knowledge that improves the function and/or quality of life for individuals with spinal cord injury by learning about the mechanisms responsible for muscle wasting and weakness, testing effectiveness of medications that might mitigates these adverse changes, and collaborating with clnical partners to translate these advances to the clinic. Work in the laboratory focuses on three main areas of research: preventing or reversing muscle weakness in persons with disabilities; stimulating neuroplasticity and functional recovery after spinal cord injury; and role(s) of Numb in cell fusion and muscle contraction. Our work relies on a wide range of approaches such as molecular and cellular biology, cell culture models, and animal models. To further translate advances in the laboratory we collaborate with investigators who are working with cutting edge rehabilitation medicine techniques to better understand how these benefit skeletal muscle function.

Accumulating evidence suggests that both intrinsic and extrinsic factors shape the function of neural circuits within certain substructures of the adult brain. A primary goal of my laboratory is to identify mechanisms by which blood-borne factors regulate brain function in the context of aging and disease.

Researching traditional Chinese medicine, including herbal medicines and acupuncture, for treatment of asthma, food allergies, and atopic dermatitis

Exploring the use of clinical genome informatics

Studying unusual mechanisms involved in regulating gene expression

The focus of our laboratory is to explore how mitochondria impact on human health and disease

Investigating genetic and immunologic factors associated with Crohn’s Disease and ulcerative colitis (inflammatory bowel diseases)

The Samuel Cho Spine Lab represents a coalition of surgeons, fellows, residents, and students who are dedicated to advancing the knowledge and care of patients who suffer from spinal ailments and undergo spinal surgery. We achieve this through the scientific analysis of radiographic, perioperative, and clinical data in order to develop algorithms and methods that influence surgical strategies and patient-centered treatments to achieve optimal outcomes.

The Chu lab is focused on using zebrafish to study sugar metabolism, p53, and cell proliferation in early development and cancer.

Investigating cognitive and affective impairment through

Using molecular and electrophysiological approaches, including optogenetic stimulation, to identify impact of associative fear conditioning on neural pathways and neurons in limbic and cortical regions

Developing computational methods to better understand the microbial world

Biomarkers, Clinical Trials and Quality Improvement in Nephrology

The Cohen Laboratory is focused on host-microbial interactions mediated by bacterial small molecules, proteins, and other effectors. The laboratory uses a combination of culture-dependent and independent techniques to isolate bacterial effector molecules that interact with host pathways. The laboratory is specifically interested in the manipulation of host pathways with regards to inflammation, immunity, and metabolism

The Crary Laboratory uses classical histopathological, genetic and cellular approaches to advance our understanding of the pathogenesis of the neurodegerative tauopathies. The laboratory focuses on primary age-related tauopathy, traumatic brain injury and their relationships to classical Alzheimer’s disease.

Studying neural mechanisms of sensorimotor integration

Investigating B, T cell and dendritic cell immunity in primary immunodeficiency diseases

Investigating podocyte-endothelial cell-podocyte crosstalk in CKD, examining mitochondria and the role of reactive oxygen species signaling and/or stress in glomerular endothelial cells, and defining a panel of glomerular endothelial injury factors in urine and serum to predict CKD progression.

The study of signal transduction networks at multiple levels: structurally, biochemically, within cells, and also within whole animals

Researching various aspects of thyroid autoimmune disease

We study the developmental defects resulting from disruptive mutations in novel high-risk genes identified from our ongoing large-scale genomic studies in autism (ASD) and intellectual disability (ID). We take a genetics-first approach for functional analyses in cellular and mouse models and we strive to take into account clinically relevant aspects that emerge from patient-based research.

Researching drug discovery and development

Researching molecular mechanisms in neurology

The Do laboratory is focused on understanding the genetic and biological basis of complex disease in humans. We pursue this research by developing and applying methods in human genetics, genetic epidemiology, statistical genetics and population genetics to large-scale human genotyping, sequencing and functional datasets

Understanding the early steps of B cell lymphomagenesis

Our goal is to understand vascular contributions to cognitive impairment and dementia, and to develop new therapies that protect brain function in the face of Alzheimer's, CADASIL, and other neurodegenerative diseases.

Researching optical methods and neurophysiology

Enamorado lab is focused on understanding the neuroimmune regulation of injury and repair at the barrier tissues.

Researching into Methyltransferases in Development and Disease.

Investigating host pathogen interactions that affect viral tropism and disease outcome, with a focus of those of the hepatitis C virus

The Experimental Psychopathology Laboratory (EPL) conducts laboratory and “real-world” studies of cognitive, affective, and behavioral processes and their link to psychopathology. Our work centers on two primary areas: 1. The use of translational approaches to elucidate the mechanisms of development and recovery from psychopathology. 2. The development and dissemination of cognitive and behavioral interventions to improve cognitive, affective, and social functioning.

Elucidating the molecular mechanisms that control epidermal stem cells during development and into adulthood with a specific interest in the role of chromatin regulators in these processes

Applying experimental and computational tools to understand interactions between diet, the microbiota, and human health

Tendon and ligament disorders relate to 30% of general practice consultations for musculoskeletal pain and bring an extremely high socioeconomic burden. Our lab aims to better understand mechanobiology, cell biology, and development biology to pave the way for developing tissue engineering strategies and cell-based therapies to regenerate and rejuvenate tissues.

Epigenomes of bacteria, microbiome, human: technology development + systems biology of human diseases. We are most excited to characterize largely unexplored, or unknown, forms of nucleic acid modifications. Our goal is to fundamentally understand the diversity, landscape and functions of these "hidden" modifications, and translate basic science into actionable strategies for the diagnosis and treatment of human diseases.

The Federman Lab addresses self-management of complex chronic illnesses by older adults, with a special focus on the impact of cognition, health literacy, and illness-related beliefs.

Investigating the mechanisms of viral immune evasion

The Ferrara Laboratory investigates the immunology of bone marrow transplantation (BMT), particularly its major complication graft-versus-host-disease (GVHD). Through trailblazing techniques the team has identified and validated unexpected biomarkers for skin, gut, and steroid-resistant GVHD.

The Ferrari de Andrade Lab studies how proteolytic cleavage of surface proteins affects immunity against cancers.

Engaging in computer-aided structural biology and drug discovery

Exploring intricate processes of cell division

At the Foss-Feig Lab, our research combines clinical assessments with brain-based methods, including EEG and MRI, to examine sensory and perceptual functioning in autism spectrum disorder (ASD). We also study the relation between ASD and other neurodevelopmental disorders, including schizophrenia and psychosis prodrome, as well as monogenic disorders with a prominent ASD phenotype.

Our goal is to provide a better understanding of the molecular machinery that drives proliferation, invasiveness, and therapy resistance of brain tumor cells.

Exploring links between hepatic autophagy, fibrosis and progenitor cell amplication; bioinformatics assessment of stellate cell biology; studying pathogenesis of hepatic fibrosis, testing of antifibrotic therapies.

The focus of the lab is to understand the links between obesity, type 2 diabetes and breast cancer progression, with a specific interest in the roles of cholesterol, cholesterol metabolites.

Researching brain tumors; neuro pharmacology; and chemotherapy

The Galynker Suicide Research Laboratory investigates the psychological processes that make suicidal behavior possible. We conduct clinical research focused on understanding the Suicide Crisis Syndrome (SCS), which is a negative cognitive-affective state associated with imminent suicidal behavior in those who are already at high risk for suicide. We also investigate the mechanisms by which traditional long-term risk factors such as mental illness or histories of past attempts interact with the SCS to increase risk of suicide in the immediate future.

The laboratory’s research focuses on developing innovative and effective therapies for pancreatic beta cell preservation, immune tolerance and pancreatic beta cell regeneration for the treatment of diabetes.

Exploring virus-host interactions

Dr. Gelb has developed an extensive program in genomics focusing on traits associated with heart malformations. The Gelb lab is studying Noonan and related syndromes, which arise from defects in RAS/MAPK signal transduction. Ongoing studies are using RASopathy induced pluripotent stem cell models and fruit fly models to elaborate disease pathogenesis and for drug discovery. The Gelb group is also studying congenital heart disease as a complex genetic trait, working with the Pediatric Cardiac Genomics Consortium (PCGC). The PCGC is applying various ‘omics’ approaches to discover the causes of these birth defects. In addition, the Gelb group is undertaking functional genomics studies using patient-derived induced pluripotent stem cells.

Studying methods and applications of genetic testing

Our laboratory focuses on the role of mitochondrial unfolded-protein response (UPRmt) in breast cancer

The Ghaffari lab is focused on exposing mechanisms that maintain healthy blood stem and progenitor cell production throughout life that are perturbed in disease. The ultimate goal of the lab is to explore these mechanisms for therapy by improving blood production and interfering with disease.

Despite optimal use of traditional therapeutic approach to atherosclerotic cardiovascular disease (CVD) morbidity and mortality due to myocardial infarction (MI) and stroke remain high and continue to rise globally. Inflammation and immunity are key processes in the pathogenesis of atherosclerosis—and promising targets for new therapies to treat cardiovascular disease. Our goal is to identify immune regulatory networks and signaling pathways relevant to human atherosclerosis to improve data-driven selection of suitable molecular targets for novel anti-inflammatory and immune-modulatory therapies in cardiovascular disease

The Ginzburg laboratory is focused on understanding the interface of erythropoiesis and iron metabolism to develop new targeted therapies for the clinical management of iron overload anemias (e.g. β-thalassemia, sickle cell anemia, anemia of inflammation and cancer, myelodysplastic syndromes, and myeloproliferative diseases). We are evaluating the role of novel regulators involved in the coordinated physiology of hemoglobin synthesis and exploring incompletely understood regulation of iron metabolism in dyserythropoietic diseases.

Research in our laboratory focuses on dementia (Alzheimer's disease & frontotemporal dementia) and addiction (alcohol dependence)

The Laboratory for Biological Systems in Stress and Disease studies the systems-level biology of emotional memory and stress in healthy rodents and humans, and examines dysregulation of this biology in animal models of psychiatric disease and human patient populations. We combine modern techniques from systems neurobiology, including optogenetics, in vivo recordings, gene transfer, microarrays, and in vivo calcium imaging, with classic techniques from neuropharmacology, endocrinology, molecular biology, and behavioral neuroscience to address research questions. Our long-term mission is to advance new frontiers in basic science with high translational relevance and provide new biologically-driven, effective treatments for stress-sensitive disease.

The research in this laboratory is focused on identifying the components and molecular mechanisms regulating actin architecture in cardiac and skeletal muscle during normal development and disease. Control of actin filament lengths and dynamics is important for cell motility and architecture and is regulated in part by capping proteins that block elongation and depolymerization at both the fast-growing (barbed) and slow-growing (pointed) ends of the filaments.

Our research examines the neural and computational mechanisms underlying human beliefs, decision-making, and social interaction in both health and disease using fMRI, lesion, neuropharmacology, and computational modeling.

We seek to obtain a deep understanding of skin immune reactions in the setting of both systemic and topical immunotherapies. We accomplish this by leveraging single-cell and spatial multi-omic approaches applied directly to patient skin tissue.

Discovering new genes implicated in (RA), identifying prognostic biomarkers and generating new targets and more effective therapies to cure RA and other autoimmune diseases

Dr. Guttman’s groundbreaking research focuses on atopic dermatitis/eczema and contact dermatitis. Her research has important implications in advancing the current molecular knowledge on atopic dermatitis/eczema and developing new therapeutics. Dr. Guttman currently develops biomarkers of atopic dermatitis that could be used for future studies with targeted therapeutics. She also concentrates on unraveling the primary pathogenesis of this common disease.

The Gümüş Lab develops and applies computational methods and tools used in cooperative team efforts to define and implement genomics-based precision medicine approaches.

Our specific research areas are focused on SIN3a complex epigenetic regulation of gene expression, and gene therapy in vascular physiopathology and progressive coronary artery disease, pulmonary arterial hypertension, and heart failure.

We investigate epigenetic changes in disease and normal human postmortem brain samples, providing a snapshot of potential epigenetic abnormalities associated with disease neuropathology

Exploring neurophysiology as it relates to depression and alcoholism

Enhancing nerve function, motor control, and resilience after spinal cord injury and amyotrophic lateral sclerosis. Our research interventions include: Electrical spinal stimulation, magnetic brain stimulation, targeted physical exercises, ischemic pre-conditioning, new uses for old drugs, electroencephalography, and more.

Research on our lab is focused on understanding the mechanisms by which autism-associated mutations lead to the manifestation of behavioral deficits, with an emphasis on the effect of these mutations on the brain oxytocin system, known as a major modulator of mammalian social behavior, and on brain circuits of social behavior. Our lab applies integrated molecular and behavioral neuroscience approaches and uses transgenic rat models for ASD and neurodevelopmental disorders to identify molecular targets for treatment and to uncover altered brain circuits that can be manipulated with circuit-specific non-invasive interventions.

The Hausman/Cagle Lab investigates the mechanisms of peripheral nerve damage and focuses on identifying novel diagnostic tools and treatments to ease the burden of these injuries. Another aspect of our research involves translational joint biomechanics studies to assess the strength and feasibility of a variety of treatments for injuries of the upper extremity.

Utilizing functional brain imaging (e.g., fMRI ( functional magnetic resonance imaging) together with more basic psychophysiological measures (e.g., skin conductance responsivity and modulation of the startle eye blink response) to examine emotion regulation in Veterans at risk for suicide.

Investigating role of retinoic acid in podocyte biology and pathology; Role of HIPK2 in kidney fibrosis; Using systems biology approach to study kidney disease; Pathogenesis of HIV-Associated Nephropathy; Pathogenesis of diabetic kidney disease

We integrate MRI and PET brain markers to help build a comprehensive picture of how aging and neurodegenerative disease affect the relationship between brain function and cognition at an individual level, with the aim of accelerating diagnosis and improving evaluation of therapeutic interventions.

Translational research in the field of transplantation biology

The Hildebrandt Lab is dedicated to research of the neurobiology and treatment of eating, weight, and body image disturbance across the age spectrum. We use a mixture of neuroimaging, psychophysiology, neurocognitive, and endocrine assays as well as integrated technology solutions to inform the creation of new treatments for these populations. Results from our work in our lab continue to help us to develop, implement, and disseminate empirically supported treatments to our patients and their families.

Research into novel vaccine designs to elicit potent antibody responses to the human immunodeficiency virus (HIV).

Conducting neuromorphology research

Intervertebral disc degeneration and osteoporosis of the spine impose significant socioeconomic burdens and each may interact with the development of the other. The Holguin laboratory focuses on the adaptation of the rodent spine to factors of disease to improve translational therapy for the spine.

Identifying the neurobiological bases for disorders of balance, equilibrium, and movement

We use imaging of live lungs, among other methods, to understand how inhaled bacteria and viruses cause lung injury, and how pathogen-injured lungs are repaired and regenerated.

Perivascular astrocytes, specialized glial cells that comprise the second and most distal barrier to immune cells prior to CNS parenchymal entry

The Horowitz lab studies how immunogenetic variation of HLA and KIR genes governs the education of NK cells and focuses on strategies for harnessing NK cell helper and effector functions for antimicrobial and antitumor therapies.

The Hu Lab takes a multidisciplinary approach to better understand the molecular, cellular, and circuit mechanisms of sensory processing.

Focusing on the role of microbiota and host genetics in disease pathogenesis

The Hubmacher Laboratory focuses on the role of the extracellular matrix, the “glue” that holds cells together, in the formation and function of musculoskeletal tissues. We study mechanistic and molecular aspects of protein networks comprised of fibrillin microfibrils, ADAMTS proteases and ADAMTS-like proteins and their roles in musculoskeletal development.

The Huckins Lab focuses on understudied psychiatric disorders. In particular, we are interested in disorders affecting women, children, and vulnerable populations.

Our research has been focusing on the treatment for mal de debarquement syndrome (MdDS) and on reducing motion intolerance, including visual intolerance.

Researching synaptic circuit development, and neural plasticity

Studying the neurobiology of underlying drug abuse and related psychiatric disordersy

Developing minimally invasive interventions to prevent and repair painful intervertebral disc pathologies

The goal of the “In vivo imaging of metastasis lab” is to focus on understanding how tumor cells disseminate during metastasis and how the interaction with the tumor microenvironment, in particular the extracellular matrix, determinate the fate of disseminated cancer cells.

Elucidating the physiological and molecular mechanisms involved in cardiovascular pathophysiology and defining physiological and molecular changes associated with LV loading and unloading

Researching molecular basis of human malformation disorders including craniosynostosis, oral clefting, limb disorders and syndromes

Aiming to reduce cancer-related health disparities across genders and disease sites

The Ji Lab is focused on leveraging single-cell and spatial genomics to dissect intercellular communication networks driving skin homeostasis and cancer. Our goal is to translate this knowledge into novel patient treatments.

Engineer CRISPR-based genome editing tools into next generation gene therapy methods for treating versatile human genetic diseases

The Jiang Lab builds technologies such as CRISPR functional genomics and single-cell transcriptomics to fuel new discovery in diverse microbial systems. Our research focuses on understanding bacterial genetic interaction networks, evolution, antimicrobial resistance, single-cell behaviors, bacteria-phage and host-bacteria interactions. We are also interested in engineering commensal bacteria to promote human health.

Focusing on medicinal chemistry, chemical biology & drug discovery and utilizing a systematic approach to create highly potent and selective small molecule inhibitors of protein methyltransferases. In addition, the Jin Laboratory is pursuing discovery of functionally selective ligands of G protein-coupled receptors (GPCRs)

Our research is focusing on drug discoveries for neurological and psychiatric disorders. Our approach is to simultaneously target multiple disease mechanisms to increase the likelihood of clinical success.

Developing advanced magnetic resonance techniques to study neurological and psychiatric disorders

Our Lab investigates gynecologic precancers and cancers, with the goal of unraveling the secrets of carcinogenesis and, identifying prognostic biomarkers to improve therapeutics. Specific areas we have studied include: i) predictive markers of endometriosis giving rise to ovarian endometrioid and clear cell cancers, and ii) prognostic and therapeutic value of nuclear pore protein NUP62 and nuclear transport protein CRM1 in ovarian high-grade serous carcinomas.

Developing predictive, dynamical models of biological systems for bioengineering and precision medicine

Housed in the Department of Geriatrics and Palliative Medicine at the Icahn School of Medicine at Mount Sinai, our mutli-disciplinary team conducts research aimed at improving the care of seriously ill older adults. With expertise in health services research, clinical care delivery, and epidemiology, our lab uses Health and Retirement Study (HRS), National Health and Aging Trends Study (NHATS), and Centers for Medicare and Medicaid Services (CMS) data to conduct research that can inform policies and care models that impact seriously ill older adults and their families.

Analyzing human genetic variation to address fundamental questions in biology, medicine, and anthropology

Researching applications in behavioral and molecular neuroscience

Studies the role of post-translational modifications of key proteins involved in physiological function in the heart

The Kim Lab studies outcomes in patients with gastroenteropancreatic carcinoid and neuroendocrine tumors, with focus on improving prediction of outcomes and comparative effectiveness research.

The Kontorovich laboratory studies genetic traits that modulate risk and evolution of cardiovascular diseases. The work includes investigations of a number of cardiovascular disorders from a phenotype-first or genotype-first approach.

Exploring arteries of the heart; atherosclerosis, fibromuscular dysplasia, and other cardiovascular diseases

Developing broad and effective vaccines against viral pathogens

Studying pattern formation and cell differentiation during development and tissue regeneration

Studying ion-translocating membrane transporters in bacterial cells

The Kumar lab works on understanding the contribution of the intracellular stress response, specifically the Endoplasmic reticulum and mitochondrial stress response, and their crosstalk in diseases. We currently focus on the corneal endothelial cell, which degenerates and dies in Fuchs Endothelium Corneal Dystrophy. To understand disease pathogenesis, we use cutting-edge cellular and molecular biological techniques, genetics and pharmacological tools, single-cell genomics, RNA seq, large datasets, etc.

Offering an extensive set of routine and complex tests for accurate diagnoses and optimal treatment plans

Looking at the behavioral and neural mechanisms that underlie subthreshold thought disorder and emotional recognition deficit in individuals at clinical high risk for psychosis followed prospectively for psychosis and functional outcomes.

Studying energy homeostasis in disease using chemical biology

Understanding the role of insulin and insulin-like growth factors in health and disease, including the factors which explain the increased risk of cancer, especially triple negative breast cancer, and cancer-related mortality in obesity and type 2 diabetes

Targeting molecular and cellular pathways to improve contractile function and survival in failing cardiac myocytes

Researching molecular and cellular nature of the undifferentiated stem cell states, and how they are altered during a change in cell fate

Investigating the mechanism underlying the predilection of prostate cancer to metastsize to bone.

Studies the cellular immune response to vector-transmitted viruses, such as West Nile virus, Zika virus, and tick-borne encephalitis virus. We focus primarily on how cytokine responses and cell trafficking events affect the pathogenesis of these viruses.

We study the mechanisms whereby specific immune molecules (cytokines and chemokines) affect the function of the epithelial, immune, endothelial, and stromal cells from the intestine in health and disease.

Primary Focus on understanding the molecular pathogenesis of liver cancer, generating a genomic classification and discovering novel targets for more effective therapies